Sunday will mark the second time these two AFC South opponents meet this season, as the Texans' defense stifled the Titans in Week 4's 38-14 dismantling.
Here's your guide for Sunday's action.
Where: LP Field, Nashville, TN
When: Sunday, Dec. 2 at 1 p.m. ET
Spread: Titans (+5.5) via Bet Online
Frankly, I'm shocked the spread is as low as it is.
Houston has won five in a row, and although the past two were overtime thrillers against inferior teams, I love the Texans in this matchup giving just five and a half points.
The Texans' D is too good to let Locker and Chris Johnson have their way, making this an easy selection.
Go with Houston.
Over/Under: 47 (Bet Online)
When these teams got together in Week 4, they combined for 52 points, which is why I'm taking the over.
With Kenny Britt back in the mix for the Titans—he didn't play against Houston in Week 4—Tennessee is a better offense. Combine that with a Houston offense that ranks No. 3 in the league in total offense (394.8 YPG) and I'll roll with the over.
Texans (via USA Today):
TE Owen Daniels—Back—QST
T Derek Newton—Knee—QST
DE Antonio Smith—Ankle—QST
LB Brooks Reed—Groin—QST
LB Bradie James—Hamstring—QST
Titans (via USA Today):
LB Colin McCarthy—Concussion—QST
DE Derrick Morgan—Knee—QST
Fantasy Big Plays:
Texans: Andre Johnson
Andre Johnson flipped his beast mode switch on these past two weeks, combining for 23 catches, 461 yards and a touchdown.
Facing a Titans defense that has surrendered 22 touchdowns and more than 3,000 yards to receivers, you would be classified as insane if you didn't have Johnson in your lineup, as he's bound to explode in Week 13.
If you're looking for more fantasy studs who are poised for a big week, click here.
Titans: Chris Johnson
He started the season off poorly, but Chris Johnson has really turned it around.
Prior to his 80-yard day against Jacksonville in Week 12, Johnson had back-to-back 100-yard weeks with touchdowns.
And speaking of 100-yard games, Johnson had his first of the season back in Week 4 against, you guessed it, the Texans.
ESPN's Matthew Berry ranks Johnson as the eighth-best RB for Week 13.
Keys to Texans Win: Attack Through the Air
Tennessee's defense is just bad all around, but I really see an opportunity for the Texans to exploit them through the air.
The Titans are giving up more than 260 YPG through the air, and from what we saw Matt Schaub do against another bad defense, the Jaguars (527 yards and five touchdowns), attacking through the air is the obvious choice, especially with the way Johnson is dominating opposing secondaries.
I'm expecting big days from Schaub, Johnson and Owen Daniels in the passing game on Sunday as well as big plays from Arian Foster, who will help open up the passing game.
Keys to Titans Win: Utilize Kenny Britt
Britt was absent for the Week 4 matchup with the Texans but Tennessee needs to get him the ball on Sunday if they want to win.
At 6'3", Britt is the biggest wideout on the Titans and arguably has the most skill, yet he hasn't been utilized to his full ability in the Titans' offense, as evidenced by his highest-yardage game being 67 yards against the Chicago Bears.
With just two touchdowns and 30 receptions this season, Britt needs to be further integrated into the offense, which gives Tennessee its best shot at winning this Sunday.
Prediction: Texans 31, Titans 20
All the signs point to a Texans win and I'm following them. Houston has the better offense and defense, and playing on the road isn't going to affect them.
Schaub and Johnson have something special going of late and that'll continue on Sunday as Houston covers the spread.
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