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New England's streak of nine straight OVERs will continue and Dallas's streak of eight straight failures at home will continue.
Jacksonville will make it 7-0 ATS as a road team and the Buccaneers will make it 6-0 ATS as a road team.
This is all according to the NFL predictions computer at OddsShark.com, which has been both hot and cold so far in 2012.
"The computer hates home teams in Week 13 as it has roadies going 12-2 ATS," explained football analyst Jack Randall at OddsShark.com. (Two games remained off the board as of press time, so the computer did not have a prediction on the Steelers-Ravens game or the Raiders-Browns game, although both games featured significant Week 13 trends.)
Ironically, with all the road teams picked to win, the week opens Thursday with the Falcons covering the home spread against the Saints.
After that, Houston will win 36-16 at Tennessee and New England will pummel the Dolphins 40-23 in two early games featuring big road spreads (-5.5 and -6.5 respectively as of press time).
The week ends Sunday night with the Cowboys winning 20-13, but not enough to cover the 10.5-point spread against the free-falling Eagles.
And Monday Night Football sees the other two NFC East teams battling in Washington. The Giants are favored and will win 32-26, according to the computer.
Check out the Week 13 predictions below. The computer was 8-4 SU last week, but just 4-7-1 ATS, so buyer beware.
New Orleans 25.9 Atlanta 32.6 -3 ATL 55.5 O
Houston 35.8 Tennessee 16.4 +5.5 HOU 48 O
Indianapolis 20 Detroit 22.7 -3.5 IND 51 U
Jacksonville 13.1 Buffalo 17.1 -7 JAC 45 U
Carolina 16.7 Kansas City 8.7 +2.5 CAR 40.5 U
New England 39.5 Miami 23.4 +6.5 NE 51 O
Minnesota 23 Green Bay 25.6 -9 MIN 47 O
San Francisco 31.2 St. Louis 15.8 +6.5 SF 41 O
Seattle 22.5 Chicago 28.7 -3 CHI 38 O
Arizona 16.6 NY Jets 14.6 -3 ARI 37.5 U
Tampa Bay 30.2 Denver 33.9 -7 TB 51.5 O
Pittsburgh 23.3 Baltimore 27.2 OFF P
Cleveland 19.9 Oakland 10.9 OFF P
Cincinnati 26.2 San Diego 23.7 -2 CIN 47.5 O
Philadelphia 13.1 Dallas 20.2 -10.5 PHI 43 U
NY Giants 32.4 Washington 26.2 +2.5 NYG 51 O
All odds, stats, quotes and trends mentioned courtesy of OddsShark.com. Mike Pickett is an Analyst to Bleacher Report and contributes to the Twitter feed.