It all comes down to counter punching. Marquez is one of the best in the business when it comes to that, and he must use that to his advantage if he hopes to topple Pac-Man in front of the MGM Grand Garden Arena's crowd on Saturday.
Countering Pac-Man's aggressive approach will force Pacquiao to think. He's not the strongest defensive boxer, and he's susceptible to quick flurries.
Watch Marquez here:
Around the 40-second mark he shows how quick he can be. This keeps Pacquiao on his heels and doesn't allow him to be on the offensive. Neutralizing Pac-Man's power is half the battle, and Marquez can do that by stringing together rapid combinations.
He also must approach the later rounds in a different way this time. In the past three fights between these two, Marquez was too laid back as the fight progressed. He must show more urgency, forcing Pacquiao to fight his best when it matters the most.
Picking up the pace in the fight's final stanzas will test Pacquiao's stamina and could leave him vulnerable to a power punch.
It's going to take more than technically sound boxing to defeat Pacquiao. Marquez understands how to fight as well as anyone, but his approach must be flawless on Saturday. He must be willing to adapt, depending on how his counterpart decides to attack him throughout the fight.
If Marquez can catch Pacquiao this will be interesting. Pac-Man is very aggressive, and he tends to leave himself wide open at times. Marquez has enough power to hurt him, but he must be focused when the time arises.
Pacquiao's best defense is his offense. If he attacks too much though, Pacquiao's offense will also be his demise on Saturday.
For Marquez, it's all about reacting the right way at the right time.