Notre Dame (11-0) and USC (7-4) have been bitter rivals since the series began in 1926, and you better believe the Trojans hope to ruin the Irish title hopes.
Each program has won 11 national titles and boasts seven Heisman Trophy winners.
This one is for all the marbles.
If the Irish win, they go to the BCS title game for the first time.
With Matt Barkley out, this game plays right into their hands.
Six of Notre Dame's 11 wins have been by seven or fewer points, and you better believe freshman quarterback Max Wittek will struggle against the Irish defense.
Read on for a unit-by-unit comparison of the two competitors in the Game of the Week.