New Orleans has completely turned around its season after an 0-4 start, and at 5-5 it is very much in the playoff picture.
Meanwhile, the 49ers have not lost since Week 6, although a tie against the St. Louis Rams could hurt in the standings. However, a big 32-7 win over the Bears has the team back on track.
With one of the league's top offenses versus the No. 1 scoring defense, this is certain to be one of the best games of the week.
Where: Mercedes-Benz Superdome, New Orleans, La.
When: November 25 at 4:25 p.m. ET
Live Stream: NFL Sunday Ticket
Betting Line: 49ers (-1.5) via Vegas Insider
Injury Report (via ESPN) as of Nov. 20
QB Alex Smith (Concussion) Questionable
WR Randy Moss (Finger) Probable
RB Frank Gore (Ribs) Probable
RB Darren Sproles (Hand) Questionable
DE Junior Galette (Ankle) Questionable
What They're Saying
The big story following the Monday Night Football game against the Chicago Bears is the potential quarterback controversy on the 49ers between Alex Smith and Colin Kaepernick.
Matt Barrows of the Sacramento Bee quoted coach Jim Harbaugh when he told the media, "I usually tend to go with the guy who's got the hot hand. And we've got two quarterbacks that have a hot hand."
This is telling in the fact that Smith's hold on the job is not secure. However, tight end Vernon Davis had an even bolder quote, saying, "I felt like somebody took the handcuffs off me."
Davis had not been a big part of the offense in recent weeks, but he apparently likes the potential of a new quarterback at the helm.
Fantasy Big Plays
The receiving corps is deep enough that any player can have a big week. However, Frank Gore is the safest option of the group.
He is currently in the top 10 in the NFL in both rushing yards and rushing touchdowns, and he is certain to get plenty of touches throughout the game.
New Orleans has statistically the worst rushing defense in the league, so Gore should be ready for a big day.
San Francisco has a top defense, and it will be tough for anyone on the team to be productive.
That being said, Graham has five touchdowns in the last four games and is averaging almost 80 yards per game in that time.
Against the 49ers in the second round of the playoffs, he was able to manage 103 receiving yards and two touchdowns. While he might not be able to replicate this performance, he should be able to get into the end zone at least once on Sunday.
Key Matchup: Saints Receivers vs. 49ers Secondary
In addition to Graham, Marques Colston and Lance Moore have been on fire in the last few weeks. They all know that Drew Brees will find them if they get open.
However, cornerbacks Carlos Rogers and Tarell Brown have been playing well also. Not to mention the playmaking ability of Dashon Goldson at safety.
If these players can handle their matchups, it will go a long way in deciding this game.
Prediction: 49ers 27, Saints 20
The matchup between the Saints offense and 49ers defense will be one for the ages, but there is enough fire power on offense for San Francisco to dominate.
San Francisco should be able to win this battle between two of the most talented teams in football.
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