NFL MVP odds going into Week 10 see one quarterback drop off the list amid serious injury concerns. Meanwhile another quarterback, almost forgotten while his team was mired in turmoil, makes his first appearance.
The rest of this list sees two new names emerge as outside candidates for the award. There is also another high ranking for the first overall pick in the 2012 draft.
Here are the updated MVP odds after Week 10, beginning with an honorable mention for a pair of tight ends.
No tight end in the NFL is as dynamic as Jimmy Graham. He continues to present a matchup nightmare to any defense.
Graham caught a pair of touchdowns to help key the New Orleans Saints' big win over the Atlanta Falcons. Graham dominated the NFC South front-runners with seven catches for 146 yards at a whopping 20.9-yard average.
His Falcons counterpart, Tony Gonzalez, continues to defy Father Time and set the standard for his position. The 36-year-old hauled in 11 passes for 122 yards and two scores against the Saints.
This positional battle between the old master and the young upstart is as intriguing as the race for MVP.
Both still face long odds to win the award. However, their efforts in Week 10 and for the season, as a whole, deserve an honorable mention.
Roethlisberger has been superb for the Steelers in recent weeks, and his loss would be a decisive blow for the six-time Super Bowl champions.
A prolonged spell on the sidelines would also ruin Roethlisberger's chances of securing the NFL's MVP Award.
Denver Broncos' rush end Von Miller rightfully usurps J.J. Watt as the lone defensive player on this list. Watt has had held that position for a few weeks.
However, the hulking Houston Texans' defensive lineman registered only two tackles in Week 10. He also has just one sack in three games. Miller, meanwhile, has been in dominant form.
He has registered four sacks in his last two games. That takes his season tally to 10, just half a sack short of Watt's mark.
More importantly, Miller has managed to force two fumbles, something Watt has yet to do even once. Miller's versatility is the key to Denver's defense and he is fast becoming the best defensive player in the NFL.
Despite Miller's outstanding efforts, it is still difficult for defenders to scoop the leaguewide award. So the race between Miller and Watt for the NFL Defensive Player of the Year award may be more interesting.
Last week, more than one reader called for A.J. Green to be included on this list, and the young wideout certainly merits it.
Green has quickly become the focal point of the Cincinnati Bengals' youthful offense. The second-year flanker has 58 receptions for 820 yards and nine touchdowns to his credit this season.
He is averaging 14.1 yards a reception and could already be considered the game's premier deep threat.
Green destroyed the defending Super Bowl champions in Week 10. He dominated the New York Giants secondary with seven catches for 85 yards, including a 56-yard score.
What's most impressive about Green is that every defense knows to focus on him and he still gets open deep. That's a credit to the smart scheming of offensive coordinator Jay Gruden and to Green's superior physical skills.
How is Adrian Peterson better than he ever was? Two serious knee surgeries shouldn't be the precursor to leading the NFL in rushing.
Peterson has rushed for the most yards at 1,128, 123 ahead of nearest rival Marshawn Lynch. He's averaging 5.8 yards a carry and easily boasts the most runs of 20 or more yards, at 13.
His 171 yards against the Detroit Lions in Week 10 got the Minnesota Vikings back to winning ways.
Returning as a functional workhorse is one thing. However, still offering a genuine game-breaking threat keeps Peterson as a solid contender for league MVP.
Andrew Luck has helped triple the Indianapolis Colts' win total from last season. He has thrown for 2,631 yards and accounted for 15 touchdowns—10 through the air and five on the ground.
Luck has more than lived up to his billing as the top pick in the 2012 draft. The more the Colts win, the less his rookie status should count against him in the running for MVP.
What will hurt his chances are his nine interceptions and 79.1 overall quarterback passer rating. That leaves Luck far behind many on this list.
Tom Brady continues to guide the New England Patriots' versatile offense with precise efficiency. He boasts an outstanding 18 touchdowns-to-three interceptions ratio.
In Week 10 he once again tormented the AFC East's whipping boys, the Buffalo Bills. He only posted a 60.7 completion percentage and 6.7 yards a pass. Yet Brady also threw two key touchdowns for the Patriots.
He is surrounded by many complementary pieces, but it is still Brady who makes the Patriots a force.
A bye week denied Aaron Rodgers the chance to pad his impressive numbers and MVP credentials. However, he still remains a prime contender thanks to 25 touchdowns and a 107.4 passer rating.
Rodgers is making use of every weapon at his disposal. His performances keep the Green Bay Packers a viable candidate to represent the NFC in the Super Bowl.
Drew Brees has revived the New Orleans Saints and is directing the NFL's second-best passing offense. Brees has thrown for the most yards in the league at 2,847. He's also tied with Rodgers for the lead in scoring passes, at 25.
Brees remains as decisive and a accurate as ever, and his pocket presence is the best in the game. Only the Saints' 4-5 record prevents him from being higher on this list.
However, with the diminutive field general in this form, nobody can rule the Saints out. If he takes the Saints from the brink of disaster to the playoffs, Brees should win MVP.
The Atlanta Falcons' first loss was certainly not the fault of Matt Ryan. The accurate passer threw for three touchdowns and 411 yards against the Saints.
That gives him 20 scoring passes for the season, 2,771 yards and a 102.6 rating. Ryan's strong-armed precision, combined with Gonzalez, Julio Jones and Roddy White, gives Atlanta the NFL's most dangerous passing attack.
Don't expect the Falcons to be derailed by one defeat with Ryan having this kind of year.
Peyton Manning deservedly regains the top spot after another peerless showing in Week 10. Manning led the Denver Broncos' domination of the Carolina Panthers with 301 yards and his 21st touchdown of the season.
That was enough to keep Manning as the league's highest-rated passer. He has a 108.0 quarterback rating and only six interceptions.
Much like Peterson, it is amazing to see Manning as good as ever after such a serious recent injury history. Manning's average of 300.6 yards per game has transformed the Broncos offense.
Denver now relies on the quick-strike, big-play attack every fan associates with Manning. That is making the Broncos legitimate AFC contenders and Manning the current favorite for MVP.