The star forward is set to miss three months after receiving an injection in his knee to treat patellar tendinosis.
Granger is the Pacers' primary offensive option so his absence is a huge blow to the team. They are looking to earn a spot in the Eastern Conference Playoffs this year and doing so without last year's top scorer will be extremely tricky. It will be especially difficult since he's expected to miss roughly 46 games.
But the show must go on without him.
Here are three players who can step up in the mean time.
Pietrus is a great defensive player capable of playing shut down defense. He has a career average of 8.4 points a game in addition to grabbing 3.1 rebounds.
Last season, he didn't see many minutes as he came off the bench for Boston but he was effective in nailing timely three pointers to help the team win critical games.
Pietrus may not be as versatile a player as Granger is, but he can spread the floor and gives the Pacers another scoring option.
George Hill is one of three Pacers scoring in double-digits this season. The point guard is entering his fourth year in the league and has shown some promise for Indiana. Since he's played the first game of the season on Oct. 31, Hill's points have steadily increased each game. He's managed to put up big numbers even while battling hip pain which is a good sign for the Pacers. Hill isn't considered a go-to player for Indiana, but for right now, he's getting the job done, posting up the points they're missing with Granger gone.
Last season, Hibbert was an All-Star with 12.8 points and 8.8 rebounds. He was a bright spot for Indiana all season, but this year is a different story. His stats have taken a bit of a dip as he's averaged just 8.4 points and 7.6 rebounds so far. It's only been five games and besides one disappointing game against the San Antonio Spurs on Nov. 5, Hibbert has been consistent. As the season progresses, so should his stats.
The Pacers are currently tied for third overall in the Central Division with a record of 2-3. They are 29th in assists and 27th in points per game. After five games, it may be easy to judge the course of their entire season, but there are 77 games left to play.
Granger may be gone for the bulk of the season, but the Pacers have no other choice but to rely on the rest of their roster.
Will they make it far without him? Only time will tell.