San Diego comes in having lost three of its last four, while the Bucs have won three of their last four.
Sunday's game will not only serve as the kickoff of the second halves of their respective seasons, but perhaps just as importantly, the start of their quests for postseason viability.
For the Chargers, the task at hand is simple: beat a Tampa Bay team whose four victories have come at the expense of teams with a combined win-loss record of 11-22.
The Bucs' four losses have been against teams that are a combined 15-19.
With that in mind, here are the keys to the game for the Bucs in their chase for their fifth victory.