NFL Week 10 Picks: Indianapolis Colts vs. Jacksonville Jaguars

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NFL Week 10 Picks: Indianapolis Colts vs. Jacksonville Jaguars
Sam Greenwood/Getty Images

NFL handicappers are going to have a difficult time backing the Jacksonville Jaguars as one of their against-the-spread (ATS) picks this week, as they get set to face the Indianapolis Colts on Thursday night at EverBank Field, with the opening kickoff scheduled for 8:20 p.m. ET on the NFL Network.

The Jaguars are four-point home underdogs in the current Week 10 NFL betting odds (courtesy of SBR Forum), while the total has settled in at 42.5.

Quarterback Blaine Gabbert earned his first fourth-quarter comeback in a 22-17 victory over the Colts as three-point road underdogs on Sept. 23, but Jacksonville has been outscored by a significant 126-34 margin in losing all four of its games at home this season.

Let's take a closer look at this AFC South affair from a betting perspective, while offering a pro football prediction along the way.

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