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This was an outstanding fixture last season, particularly the match at the Etihad where City beat Spurs 3-2 with a very late Mario Balotelli penalty.
At that time, Spurs were on a great run of form and there was even talk of them making a tilt at the title.
They were 2-0 up and cruising after an hour, but two quickfire Spurs goals from Jermain Defoe and Gareth Bale brought things level until a tight and tense finale ended up with Mario Balotelli scoring the winner.
These two sides couldn't be in more strife right now.
Roberto Mancini is under severe pressure, despite still being unbeaten in the league.
It's fair to say that City did get the toughest Champions League group, but let's look at things objectively.
With the greatest of respect to the players at that level, it's not like Mancini is picking non-league players to play in the Champions League.
He's picking players who are hugely experienced at club and international level, not novices.
Most of his players are champions. It's about time some of them started to play like it.
Andre Villas-Boas arguably returns to the city where he has had his best results so far as Spurs boss.
Six weeks or so ago, AVB took Spurs to Old Trafford when some pundits (not including me, I actually tipped them to win) thought they didn't have a chance in hell of winning.
When it was all said and done, Spurs came out with a 3-2 victory and all three points.
Can they do the same this Saturday?
It's hard to tell.
They've been blowing hot and cold recently, with fans becoming frustrated at AVB's insistence on playing with just one out-and-out striker.
As frustrating as it must be for the fans, they need to remember, he's not playing with a defensive strategy.
Players like Moussa Dembele, Clint Dempsey, Gareth Bale, Aaron Lennon and Jermain Defoe aren't known for tracking back.
They like to get forward and score goals.
If Spurs can unsettle City early on Sunday, just like they did at Old Trafford, then they'll hand City their first defeat of the season and at the same time, put an impressive feather in the cap of AVB.