In uncharacteristic fashion, Messi was unable to score when the two sides faced each other in late October at Nou Camp.
However, the Argentinian wasn't the only Barca player to struggle at home against the Scottish champions. They trailed much of the first half after an early goal by Georgios Samaras, and it took an Andres Iniesta goal as well as an extra-time score by Jordi Alba to secure a 2-1 Barcelona victory in dramatic fashion.
Celtic will undoubtedly be motivated after their strong showing in a hostile environment against the European giants, and playing at home will aid them even further.
Though, the Scots have no answer for Lionel Messi.
Messi was his usual pesky self in the first match between these two foes, but the fact that he wasn't included on the scoresheet indicates a weak game from the striker.
Don't expect the same to occur Wednesday at Parkhead.
Messi is undisputed as one of the top two players in the world, and while Celtic certainly possesses the talent to hang around with Barcelona, they won't be able to handle a player of world-class talent such as Messi for more than one match.
Messi, one of the hardest working players in the sport, has definitely spent the necessary time looking at film to figure out what went wrong during the first go-around.
While Celtic may have the drive and belief in themselves to play another strong match, Barcelona will learn from the mistakes they made and won't have to gut out a late victory this time around, despite playing on the road.