Two weeks ago the reverse fixture took place at Anfield, with the Reds triumphing 1-0 thanks to a Stewart Downing goal.
That win put Liverpool top of the group, but it might be something of a different team that the Reds put out for this game with Chelsea awaiting in the Premier League on Sunday.
Though Anzhi are based in Dagestan, the match will take place in Moscow. Liverpool will nonetheless have a big challenge ahead of them to come out of the match with anything at all—though they know even a point would put them a big step closer to qualification for the knockout rounds.
Here are the five key battles of the match.