Carmelo Anthony scored 21 and J.R. Smith chipped in 17, including 10 in the fourth quarter.
Philadelphia, struggling mightily to stop the Knicks shooting and deadly pick-and-roll attack, couldn't find its own offense, shooting just 33 percent from the field. Jrue Holiday led the Sixers with 17, but made just four of his 15 shots.
Philly fell to 1-2 on the year.
Final Score: Knicks 110, Sixers 88