With both teams coming off their bye weeks, you can expect a few new wrinkles from the Houston Texans and Buffalo Bills.
For the Texans, that could mean a few more misdirection plays, perhaps a few more screens to the backs and tight end.
As for the Bills, they may actually utilize a new and exciting invention that has taken the NFL by storm recently but that defensive coordinator Dave Wannstedt has thus far been loathe to utilize. This invention is commonly known as a "blitz."
The Texans are arguably the most complete team in the league and should be able to take control of this game early. After allowing Aaron Rodgers to throw all over them, defensive coordinator Wade Phillips dialed up the pressure against the Baltimore Ravens. You can expect more of the same against Ryan Fitzpatrick and the Bills offense.
In the video above, we look at the biggest matchups heading into this game as well as give our predictions for the outcome. Let us know in the comments below who got it right, who got it wrong and what your pick is for the game.