How quickly things have changed.
Indianapolis is looking for their first road win—and two-game winning streak—of the season, coming off of a 17-13 win against the Cleveland Browns at home last week, a game in which they never trailed.
Tennessee, on the other hand, has won two games in a row after starting the season 1-4 and is looking to overtake the Colts for second place in the division behind the Houston Texans.
What follows is everything you need to know heading into this divisional matchup.
Where: LP Field, Nashville, TN
When: Sunday, October 28 at 1 p.m. ET
Listen: 97.1 FM (Indianapolis), 104.5 FM The Zone (Nashville)
Live Streaming: NFL Sunday Ticket
Spread: Titans -3.5 (according to Bovada.lv)
The Titans' three wins on the season have come by a combined seven points, and each of their two home wins (against Detroit and Pittsburgh) have come by a field goal. Expecting them to beat anyone by more than a field goal is a bit of a stretch.
Don't look for that to change this week against the Colts, who have picked up their three wins on the season by a combined 10 points.
As long as the spread remains more than a field goal, take the Colts getting the points in this one.
What's going to happen?
Over/Under: 47 (according to Bovada.lv)
There isn't a team in the NFL who allows more points on a weekly basis than the Titans, who are watching opposing offenses put up 34 points a game. The Colts defense isn't much better, surrendering more than 26 points to the opposition.
Neither team has what you'd consider to be a potent scoring offense, but both defensive units are bad enough where this one has shootout written all over it.
Take the over in this one.
Who Might Not Play for the Colts (via USA Today)
NT Martin Tevaseu (Ankle): Probable
LB Pat Angerer (Foot): Questionable
DE Dwight Freeney (Ankle): Questionable
DT Antonio Johnson (Illness): Questionable
DE Cory Redding (Knee): Questionable
DT Fili Moala (Knee): Questionable
RB Donald Brown (Knee): Questionable
DE Robert Mathis (Knee): Out until Early November
Who Might Not Play for the Titans (via USA Today)
LB Patrick Bailey (Chest): Probable
LB Colin McCarthy (Ankle): Probable
LB Will Witherspoon (Hamstring): Questionable
DB Tommie Campbell (Ankle): Questionable
T Mike Otto (Knee): Questionable
T Mike Roos (Appendix): Doubtful
RB Javon Ringer (Knee): Out Indefinitely
QB Jake Locker (Shoulder): Out Sunday
Fantasy Big Plays
Indianapolis: Andrew Luck, QB
Tennessee's defense is equally as inept at stopping the run as they are the pass, but as Colts beat writer Mike Chappell notes, Colts rookie QB Andrew Luck has gotten his career off to a historic start:
Chappell (@mchappell51) October 22, 2012
With the Titans allowing more than 281 yards and more than two touchdowns a game to opposing quarterbacks, Luck could be poised to put together the biggest day of his young career.
At the very least, he has an excellent shot to go over 300 yards passing with multiple touchdowns.
Coming off his first game with multiple rushing touchdowns, Luck could pick up another score on the ground as well.
Expect a big day from the first overall pick in this year's NFL draft.
Tennessee: Chris Johnson, RB
Everything you needed to know about the Colts' ability to stop the run came two weeks ago when they allowed the New York Jets' Shonn Greene to become fantasy relevant for the first time all season, carrying the ball 32 times for 161 yards and three touchdowns.
Chris Johnson is not only a far more talented running back than Greene, but he's been hot as of late, carrying the ball 37 times for 286 yards and two touchdowns over his past two weeks.
Anything less than 100 yards and a touchdown against a porous Colts run defense would be shocking, and there's a chance he could have those numbers before the first half comes to an end.
Prediction: Colts 38, Titans 34
This one is going to be back and forth all day long, with multiple lead changes and points coming at a furious pace.
While Tennessee is sure to try to eat up as much of the clock as they possibly can against an awful Colts run defense, Andrew Luck is going to have a field day against the Titans' pass defense.
Luck simply has too many weapons on offense for Tennessee to cover, and with Luck being the best QB on the field Sunday, he'll lead his team to their first road win of the season.