The Saints, who now are back in the relegation zone standing on four points and sit in 18th place in the Premier League, will hope to get at least an unlikely point and rebound from last week's dreadful performance that resulted in a 4-1 defeat to West Ham.
Spurs will also be looking to correct a short-term run of bad form. Tottenham suffered a 4-2 defeat to Chelsea in their last Premier League game and only managed a 1-1 draw against Maribor of Slovenia in Europa League play on Thursday. Three points would be helpful in Tottenham's pursuit of a top-four position.
One could expect an avalanche of goals in this fixture. Southampton have been dubbed "Europe's Most Exciting Team" by some based on the number of goals scored in their matches. Not necessarily by the Saints themselves, who have tallied a respectable 13 in eight matches, but for the 24 they have also conceded.
An average Southampton match features 4.62 goals per match, one of the highest rates in the major European leagues. Tottenham have scored 15 goals and conceded 12 in their eight Premier League matches, resulting in 3.37 goals per match.
Here's a look at the possible lineups.