In fantasy, one of the rules I try to live by is "Don't own guys that, when they get hurt, make you say, 'I KNEW he would get hurt!'"
So: Sell DeMarco Murray.
Sell right now.
Even though he's only got a sprained left foot, sell.
(Unless you are awash in RBs. If you are awash in RBs, gamble: Let him come back and hope he has a nice game. THEN sell.)
DeMarco missed almost two whole seasons at Oklahoma due to injury, then missed the end of last year, his rookie season. All the injuries were leg injuries. That's a huge red flag. That's a guy who has chronic physiological and mechanical problems.
Last year he had a sprain/fracture combination in his right ankle. In college, he had knee, toe and hamstring injuries. That is a pattern that will haunt your fantasy team.
At the end of the season will DeMarco prove to have been higher risk or higher reward?
Find an owner who is desperate for an upside play. Maybe the owner in your league who has two wins but screams that his team is "good on paper." Target somebody nice from his roster, and offer him DeMarco. Remind him "high risk equals high reward." Remind him "nothing ventured, nothing gained." Remind him of anything you have to to get him to give up a nice #2 WR, or a prime tight end or even a decent QB.
There are fantasy owners out there who hold their breath every time Murray touches the ball, every time he cuts, every time he is tackled.
Don't be one of them.