Arsenal put on a shockingly bad display in their last game, losing 1-0 to Norwich, which dropped them all the way to ninth in the English Premier League rankings.
Thankfully all is not lost for Arsenal after winning their first two group matches, who would be close to qualification by getting a win at home in the friendly confines of Emirates Stadium.
On the other side of the pitch, Schalke is coming off a big 2-1 win against Dortmund. Schalke is second in their group with four points heading to North London on Wednesday.
To make things even more interesting, Arsenal hasn't lost a game at home in 45 matches. Schalke is the only Bundesliga team that hasn't lost a competitive game on the road this season but is also 0-5 at Emirates Stadium in their last five attempts.
Where: Emirates Stadium, Islington, North London, England
When: Wednesday, Oct. 24, 2:30 p.m. EST
TV/Live Stream: Fox Sports, Fox Soccer 2go
Arsenal: Santi Cazorla
If Arsenal wants to get back to their winning ways, they'll need Cazorla to have a big game. There is a long list of Arsenal injuries coming into this game against Schalke including the electric Theo Walcott. Cazorla and the rest of the Gunners will have to make up for the injuries and play well.
Cazorla is ambidextrous which makes him a dangerous threat from either side of the field. He's got a lot of speed and has netted two goals in his eight appearances with Arsenal. If Arsenal is going to find a win on Wednesday they'll need a lot of help from Cazorla.
Schalke: Klaas-Jan Huntelaar
Huntelaar being a key player for Schalke should come as no surprise to Schalke fans. He has been phenomenal in his time with Schalke scoring 66 goals in his 90 matches with the team. This season alone he has five goals in eight appearances.
Schalke has the opportunity to win at Emirates Stadium for the first time in their last five attempts facing an Arsenal team shaken from a loss to Norwich. If they want to make it happen, Huntelaar will have to come up big.
Prediction: Arsenal 2-1
Inspired after an uncharacteristic loss to Norwich, Arsenal gets over their injuries and holds it down at home. Schalke plays well holding at 1-1 for most of the game until Arsenal finds a late goal to seal the victory.