The Cardinal are coming off a controversial 20-13 overtime loss against Notre Dame, while Cal beat Washington State 31-17 last week.
The Big Game is a crucial for both teams, and not only because it's one of the most storied rivalries in all of college football.
Stanford sorely needs a win to prove that they can win on the road.
With a win, Cal will drop their losing record to go 4-4 and 3-2 in the Pac-12.
Although Stanford seems to be the much better team on paper, the Big Game will prove to be a close, competitive matchup, and here's why.