RGIII has a chance to make an early impression on Giants fans.
The Seattle Seahawks nearly played spoiler to the San Francisco 49ers on the road Thursday night before coming up short, but that doesn't mean they're the only team with a chance to pull off a road upset in Week 7.
In fact, there are two teams that are in good position to leave the home crowd disappointed on Sunday.
Beginning in the NFC, the Washington Redskins head northeast to take on the New York Giants in the Meadowlands.
Although the Giants looked dominant in their 26-3 victory over the 49ers in Week 6, the Redskins looked equally potent in a 38-26 shootout against the Minnesota Vikings.
With Robert Griffin III at the helm, the Redskins finally feature a dynamic player at the quarterback position, and the rookie sensation should finally restore the luster to this age-old rivalry.
New York's defensive line will be a load to handle for Washington's front five, but RGIII's ability to make plays with his legs should keep the Giants defense honest.
The biggest challenge for the Redskins will be shutting down Eli Manning and his dangerous duo of Hakeem Nicks and Victor Cruz. Getting pressure on Manning with second-year outside linebacker Ryan Kerrigan could slow down New York's passing attack.
Even after losing Brian Orakpo for the year, Washington still has a solid defense that makes plays on the ball.
If the Redskins can hold the Giants to fewer than 24 points, expect RGIII to send Giants fans home with their heads in their hands.
Who will win the matchup between Houston and Baltimore?
Heading down south, the Houston Texans play host to the reeling Baltimore Ravens.
Although Houston is off to a 5-1 start, it is coming off an embarrassing 42-24 thrashing by the Green Bay Packers on Sunday Night Football.
The Texans lost star linebacker Brian Cushing for the year with a torn ACL, and their vaunted pass rush didn't exactly get a lot of pressure on Aaron Rodgers, who threw for six touchdowns.
Offensively, Gary Kubiak's team appears a little one-dimensional, as the passing game just isn't as potent as it was a few years ago.
Andre Johnson was completely shut out by Green Bay's secondary, leaving Arian Foster to shoulder the load.
Even though the Ravens did lose Ray Lewis to a season-ending triceps tear, they still have one of the better defenses in the AFC to stop Foster.
Dannell Ellerbe and Jameel McClain have experience in the defense, and the Ravens have solid depth with former second-round picks Paul Kruger, Courtney Upshaw and Sergio Kindle on the outside.
If the Ravens hope to steal a game in Houston, they'll have to put the burden on their offense.
Luckily for John Harbaugh, he has the weapons to do it.
For all the criticism he takes, Joe Flacco is still a top-10 quarterback who knows how to win in this league. Add in Ray Rice, Torrey Smith and a pair of athletic tight ends, and the Ravens should have enough juice to put points on the board in Houston.
If Flacco can engineer an efficient day for the offense and keep Foster off the field, the Ravens can join the Redskins as road teams who can pull off huge upsets Sunday.