United is four points behind first-place Chelsea in the EPL table, while Stoke is firmly planted in the middle of the pack at 12th.
Although clearly the favorites in this match, United should be pressed by Stoke, who has five draws and a win against just one loss.
They are a feisty opponent who should not be taken lightly at all by Sir Alex Ferguson's squad.
Where: Old Trafford, Greater Manchester, England
When: Saturday, October 20th, 10 a.m. EST
TV/Live Stream: Fox Soccer 2Go
There are a few interesting storylines to note heading into Saturday's fixture. The first is the potential impact that England's match against Poland could have on United.
The international contest was postponed until this past Wednesday, and Wayne Rooney, Danny Welbeck, Tom Cleverley and Michael Carrick all played in it.
Welbeck only played 23 minutes as a reserve, however, and could get the start alongside Robin van Persie.
The Red Devils will have to be concerned with Peter Crouch, the towering striker for Stoke who has five of the team's six goals this season.
He's always a threat in the air, and Stoke does a good job giving him opportunities.
Striker Michael Owen missed Stoke's last match—a defeat at the hands of Liverpool—but would surely love to take the field against United, his former club of three years.
No matter who takes the field, it will be a tough battle for United. Stoke manager Tony Pulis is a no-nonsense guy who demands his team play hard and tough.
United midfielder Nani said that he thinks it is "always hard to play Stoke...[t]hey are very physical and have very strong players...[so we will] need to be strong".
I feel that United, tired players and all, should be up for the task.
Stoke hasn't won a league match in Old Trafford dating back to 1976, and they won't be victorious tomorrow either.
Prediction: Manchester United 3 Stoke City 0