But quarterback Eli Manning put up pretty pedestrian numbers, going 15-of-28 for 193 yards, one touchdown and no interceptions against a tough Niners defense.
That's bad news for the Washington Redskins, who visit New York on Sunday, as Manning very often follows up a mediocre performance with a spectacular one.
It's all about ebb and flow.
The NFL is all about the eight-day work week, a Sunday-to-Sunday emotional roller coaster. While the past—last year, the last several meetings, the last five years—can be an indicator of future outcomes, what happened a week ago has as much impact on a game or a player as anything.
Teams riding an emotional high from a dominating win often crash down to earth, a la the New York Jets in Week 2.
Teams that get manhandled one week come back with both barrels loaded: See tonight's San Francisco 49ers rout the Seattle Seahawks as they bounce back from Sunday's demolition.
Ebb and flow.
It's the same with players.
Historically, Manning has not fared well against the Redskins, throwing for an average of 216 yards a game and tossing more picks than touchdowns, 13 to 12, respectively. And he's managed to complete only 55 percent of his passes.
Last year, in the season opener, Manning was harassed all day in the pocket, sacked four times and managed zero touchdowns against Washington.
In Week 15, a week after Manning carried the Giants on his back with a 400-yard performance to beat the Dallas Cowboys on the road, he was terrible at home, throwing three interceptions in a loss.
Ebb and flow.
Manning was not terrible Sunday against the Niners but expect him to bounce back against a Redskins secondary that, even with DeAngelo Hall anchoring the left side, is dead last in the NFL, giving up 328 yards a game.
With Hakeem Nicks back—and Domenik Hixon, Rueben Randle and Ramses Barden showing great confidence and improvement—the Giants will torch Washington, especially Josh Wilson, the weak link in the Redskins' secondary.
Don't be surprised if Manning puts up his second 400-yard performance of the season and writes a new chapter in his history against Washington.
Lou Rom covers the NFL, his hometown New York Giants, and whatever else gets under his skin for Bleacher Report. You can follow him on Twitter at louromlive.