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Peyton Manning has a knack for staging huge comebacks on the stage of Monday Night Football.
With five minutes remaining, Manning's Colts were down 35-14 and it looked like Indianapolis would suffer their first loss of the season.
A week after throwing for 314 yards and six touchdowns in the Colts' 55-21 rout of New Orleans, Manning was 34-of-47 for 386 yards, two touchdowns and one interception.
That one Manning interception was turned into a touchdown by Ronde Barber, giving Tampa a three-touchdown lead late in the final quarter.
Manning would regain his poise and lead the Colts on three-consecutive scoring drives in just over three minutes to send the game to overtime.
Manning launched the game-winning drive from his own 13. Crucial third-down completions of eight yards to Harrison, 16 yards to Reggie Wayne and nine yards to Troy Walters kept the drive alive. Mike Vanderjagt would boot a 29-yard field goal in overtime to complete the epic comeback.
Indianapolis became the first team in NFL history to win after trailing by 21 or more points with less than four minutes to play in regulation.