Johan Santana has beaten almost every Major League team in his career.
The one team he hasn't beaten is the team he won two Cy Young awards with over six full seasons.
Santana has faced the Minnesota Twins only once since being traded to the New York Mets in 2010, taking the loss after giving up five runs over five innings. But he should get another crack at them this April when the Mets are at Target Field April 12-14. It will also be the first time Santana has returned to the Twin Cities.
With the Houston Astros moving from the National League West to the American League West in 2013, there will be 15 teams in each league. There will always be an interleague series happening rather than it all happening at once at the beginning of the summer.
The Twins will also face the Miami Marlins (April 22-23, June 25-26), Milwaukee Brewers (May 27-30), Washington Nationals (June 7-9), Philadelphia Phillies (June 11-13) and Atlanta Braves (May 20-23).