One advantage to being in a must-win situation is teams will not play not to lose.
In other words, since winning becomes more imperative there won't be any resort to conservative play-calling on offense or lack of aggressiveness on defense.
An offense such as the Denver Broncos will put the ball in Peyton Manning's hands and provide him with infinite opportunities to dice up a defense. On the flip side, the Broncos will blitz relentlessly with Von Miller and co. to give the secondary playmakers additional shots at creating turnovers.
Denver needs a win in Week 6 because the Broncos are 2-3 and can't afford to fall further behind the San Diego Chargers in the AFC West. Along with Denver, though, other teams this week have their backs against the wall.
And another loss as we near the midway point would be extremely detrimental to their postseason odds.