Every week provides each NFL team with a new opponent, besides facing divisional opponents for a second time. Therefore, it's difficult to look only at statistics to find the evidence needed to pick a winner in any given game.
Some teams, such as the Arizona Cardinals, have beat up on weak competition, while other organizations have seen the Houston Texans and San Francisco 49ers already through five games this season.
More than how good the defenses can be, it's about how bad the offenses are on this list. Four of the five teams won't make the playoffs, but Week 6 will provide them with solidarity.