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Bills at Cardinals
Buffalo and Arizona face a must-win situation.
For one, the Bills just need a win to build some confidence as the AFC East sees a new contender in the Dolphins.
The Cardinals are in a similar position, because the Rams are on the rise as well.
As for this contest, Buffalo simply can't turn the ball over. Arizona's defense has pass-rush potential and playmakers in the secondary, so a run-oriented approach is likely.
Unfortunately for the Bills, the Cardinals present receiver Larry Fitzgerald and other receiver complements. The Cards may lack pass protection, but Buffalo's pass rush has yet to really make an impact.
Arizona over Buffalo
Giants at 49ers
A rematch of the NFC Championship game, the Giants travel back to San Francisco in a colossal conference matchup.
Things are a little different this time around, however, because the 49ers have Brandon Jacobs and Mario Manningham.
New York still needs more week-to-week consistency from the running game, and San Francisco remains elite on defense.
In addition, the 'Niners have improved against the pass and Alex Smith continues to improve as well, not to mention he will be going against Big Blue's banged up secondary.
San Francisco over NY Giants
Vikings at Redskins
The Minnesota Vikings have found a rhythm and aren't slowing down any time soon.
Adrian Peterson is basically back in full force, and the defense has allowed just 33 points in the past three games.
Washington, on the other hand, hasn't been as fortunate.
Defensively, the Redskins are vulnerable to the pass, which only hurts when defending the run. Offensively, the consistent explosion is lacking and there has not been enough balance to control the game tempo.
This is what the Vikings do well, and they also have special teams playmakers.
Minnesota over Washington