It will be hard to live up to the drama of last weekend as far as upsets and thrilling endings are concerned, but Week 7 will still feature some exciting games, including one of the best rivalries in the sport.
Oklahoma and Texas will square off in the Red River Rivalry, with the loser likely eliminating any chance of contending for a Big 12 title.
Once again, 22 of the Top 25 teams are in action, and this week, there are four games featuring ranked teams going head to head.
Among the other must-see games this weekend are South Carolina at LSU, Stanford at Notre Dame and Texas A&M at Louisiana Tech.
As always, there are still some non-conference games that leave a lot to be desired, including Fordham at Cincinnati.
But, for the most part, this should be another outstanding weekend of college football.
The spreads are out and it is time to break down each game with a prediction to go along with it.
*All times Eastern; odds via VegasInsider.com