After a crazy first month, the NFL returned to a sense of normalcy in Week 5 with far fewer shocking upsets aside from the notable exception of the Indianapolis Colts upending the Green Bay Packers. Otherwise, most of the favorites took care of business.
Things are looking up for the underdogs in Week 6, though. There are several upset-minded teams capable of overcoming the odds and shaking up the league again. No team is safe with parity seemingly at an all-time high.
St. Louis Rams
The Rams have rattled off two straight wins over the Seattle Seahawks and Arizona Cardinals, but are still looking for their first road win as they travel to face the Miami Dolphins. It's already a key game for both teams in terms of stay within striking distance of a playoff spot.
St. Louis will have to overcome the loss of top receiver Danny Amendola, who was emerging as a reliable target for Sam Bradford. Luckily, Brandon Gibson should be able to step up and fill the void in the short term.
The underrated Rams defense should be able to get a lot of pressure on Dolphins rookie quarterback Ryan Tannehill, who has already been sacked 10 times. A big defensive play will turn the tide in St. Louis favor, leading to the upset.
Which underdog has the best chance?
New York Giants
Whether it's a single game, such as Sunday's comeback victory over the Cleveland Browns, or an entire season, the story of the Giants remains the same. They seem to play their best when their backs are up against the wall.
That's why it's impossible to count them out as they head west to face the San Francisco 49ers, who just finished destroying the Buffalo Bills in one of the season's most impressive displays. That will serve as motivation for the defending champions.
The vaunted Giants defensive line, which has only registered eight sacks so far, is due for a breakout game and the New York offense has enough firepower to put up points on the 49ers. In one of the week's best games, the Giants will prevail.
The Lions have been one of the league's biggest disappointments, so it's not a surprise they aren't getting much respect heading into a road game against the Philadelphia Eagles. They have too much talent to struggle like this all season, however.
Detroit had the benefit of a bye week to basically press the reset button. There were high hopes heading into the season, and the added pressure certainly hasn't helped. With a week off to let the hype die down and work on fixing some defensive issues, the Lions should be ready to roll.
Although the Eagles are 3-2, including 2-0 at home, they actually have a negative point differential and haven't won a game by more than one point. The high-powered Lions offense will lead to a much-needed victory coming out of the bye.