Bills vs. 49ers: Full Highlights and Recap

The Buffalo Bills got rolled at Candlestick Park 45-3 by the San Francisco 49ers in a record-breaking display of offense from the home team.

ESPN Stats & Info:

"

49ers gained 621 yards against Bills, most ever gained by SF and allowed by BUF; previous mark for both teams was 598, set in 1992 meeting.

— ESPN Stats & Info (@ESPNStatsInfo) October 7, 2012"

Alex Smith threw for 303 yards with three touchdowns and zero interceptions, and Vernon Davis and Michael Crabtree both hauled in multiple receptions for over 100 yards.

Frank Gore also pitched in over 100 yards on the ground and a touchdown, and by the time the second half had even begun, the rout was on.

49ers runners combined on 38 carries for 311 yards and three touchdowns. 

Ryan Fitzpatrick had a miserable afternoon against the 49ers defense, throwing for only 126 yards with zero touchdowns and an interception.

Bills running backs didn't find any running room, either; as a team, the Bills only totalled 89 yards on the ground.

The Bills fell to 2-3 with the loss and travel to Arizona to face the Cardinals in Week 6, while the 49ers will stay at home with their 4-1 record and host the New York Giants—the team that beat them in the NFC Championship game last year. 

Follow me on Twitter @JesseReed78