Obviously, the big storyline this week will be the status of RGIII. After taking a monster hit along the sideline, the rookie quarterback will be dealing with a concussion and all that that implies in today's NFL.
On the other side of the ball, the surprising Vikings have mastered their formula of tough running with both Adrian Peterson and Toby Gerhart and their second year quarterback Christian Ponder making smart decisions with the football.
These two teams can run the football and will no doubt lean on the running game early and often, especially the Redskins if Kirk Cousins is under center to start the game. There's going to be a lot of hitting and lot of bruising three and four-yard runs.
The passing games for both of these teams can be sneaky dangerous, but you have think Mike Shanahan will dial things down a bit if Cousins makes his first professional start.
In the video above, we look at some of the big matchups, talk about who the hardest working player will be and predict a score for the game. Let us know in the comments below which matchups you'll be paying attention to and what you think the final score will be.