Brandon Jacobs, who said all last week that he was past an August knee injury and was ready to play, is inactive today against the Bills. Another running back, LaMichael James, also is inactive for the fifth time this season. In fact, all of the 49ers draft picks are inactive for the second straight game. The only rookie in uniform will be tight end Garrett Celek. The other 49ers inactives: quarterback Scott Tolzien, nose tackle Ian Williams, safety Trenton Robinson, guard Joe Looney and wide receiver A.J. Jenkins.