Week 5 of the NFL season presents some matchups that heavily favor some of the best quarterbacks in the league.
Let's take a look at some signal-callers who will no doubt dominate their opponents this week.
Eli Manning (New York Giants vs. Cleveland Browns)
Manning might not have his best receiver on the field this week, but that doesn't even matter. Hakeem Nicks will miss his third straight game due to injury.
But Manning has other reliable options to go to instead.
Victor Cruz has developed into one of the better receivers in the NFL and has already posted an 11-catch, 179-yard performance this season. Martellus Bennett is one of Manning's newer favorites, and the tight end has enjoyed a resurgence this season.
Domenik Hixon will also be a main option for Manning, and he's proved to be reliable after catching six passes for 114 yards last week against the Philadelphia Eagles.
The Cleveland Browns will be New York's opponent in Week 5, and that's good news for the G-Men considering the Browns couldn't stop a nose bleed. Manning should be able to have a huge day against the Browns' 28th-ranked pass defense.
Aaron Rodgers (Green Bay Packers vs. Indianapolis Colts)
Green Bay's potent passing attack didn't get off to such a great start this season, but after lighting up the New Orleans Saints for 319 yards and four touchdowns, it looks like Aaron Rodgers and the offensive unit is picking up some serious steam.
The Packers will square off against the Indianapolis Colts this week, so the numbers should be impressive after this game.
Indy's pass defense has been decent so far this season, ranking No. 16 in the NFL. But the Colts have yet to face an elite quarterback like Rodgers, so that ranking doesn't hold much water yet.
Even if the Colts' pass defense is for real, their rush defense is not. Indianapolis is ranked No. 25 against the run in 2012, and that will allow Green Bay to get its ground game going early and often.
If they take that approach, the Packers will be able to open things up for their passing attack with the Colts cheating to stop the run.
Peyton Manning (Denver Broncos vs. New England Patriots)
This game will begin with the storyline of Manning versus Tom Brady, but it will end with the storyline of how Manning scorched the Patriots sorry defense.
Which quarterback will have the biggest week?
There were many doubts about Manning's ability to still put up big numbers, but I'd say two 300-yard games in a row is evidence enough that Manning can still throw it with the best of them.
New England's defense is better against the run, ranking No. 8 in the NFL. But that won't help them this week as the Broncos' passing attack should light up the Pats' No. 25 pass defense.
While it's a certainty the Pats won't stop Manning, it isn't known just how badly the Broncos' signal-caller will dominate the Patriots defense considering Manning is by far the best quarterback New England has faced this season.
No matter what, expect Manning to have a big game against New England this week.