With 14 games on the schedule, 28 quarterbacks have a chance to prove that they can change a game. Whether it's a game-winning drive or flat out dominating the opponent, each signal-caller has sixty minutes to prove why he is on the field.
The first quarterback on the list is playing at home against the Miami Dolphins. Andy Dalton, the second year gunslinger from TCU, has played well as the Bengals are 3-1 to begin the year.
Even though the Dolphins sit at 1-3, Miami is no cakewalk. They boast the best run defense in the league giving up less than 60 yards per game.
Dalton must take advantage of the third-worst pass defense in the league. The Bengals should not abandon the run game because if the "Law Firm" can pick up some hefty gains, the play-action pass will be immensely effective.
The Bengals have plenty of weapons to help Dalton along. A.J. Green has a touchdown in each of the last three games to go with the big-play threats of Armon Binns and Andrew Hawkins, and tight end Jermaine Gresham is a solid target in the middle of the field.
Look for the "Red Rifle" to put up big numbers against the Dolphins.
Cam Newton has the honor of taking on the most frustrating team in all of the National Football League.
The Seattle Seahawks handled the Cowboys, uhh, "beat" the Green Bay Packers, and followed those two wins with a loss to the Rams.
Which QB will have the best game this weekend?
Playing against the Carolina Panthers must cause a difficult week of preparation for any team. Newton is one of the most athletic quarterbacks in the league and Seattle has yet to face someone of his running ability this season.
After being demolished by the Giants on a Thursday night two weeks ago, the Panthers almost came away with a victory against the undefeated Atlanta Falcons.
Carolina should put a ton of pressure on rookie Russell Wilson. Last week, Matt Ryan was brought down seven times behind the line including 3.5 sacks by Panthers' defensive end Charles Johnson.
If the Panthers force Wilson into a few mistakes and give Newton the ball with good field position, Carolina could run away with this one.
ESPN's Monday Night Football has the last quarterback who will take over a game.
I'll give you a hint. He was relegated to backup duty early in his career, but made the most of his opportunities to play.
And now back to reality.
Texans' QB Matt Schaub has not been statistically overwhelming, but he has done his job this season guiding Houston to a 4-0 record heading into the game vs. the Jets. He currently holds a 67 percent completion mark with seven touchdowns to just one interception.
The numbers don't have to be overpowering to get wins (see Michael Vick and the Philadelphia Eagles), but it doesn't hurt when Schaub is making plays. To this point however, the workload has been on Arian Foster's shoulders with Houston earning three 20-plus point victories.
Speaking of the running game, the Jets are allowing over 170 yards rushing each game.
If you think that the Bengals establishing the run to get successful play-action against the Dolphins is important, just wait until the Texans run right through the Jets' defense to set up the deep ball.
Prediction: Matt Schaub and Andre Johnson have monster games on Monday night.
Three quarterbacks, three games, three chances to win big.
Or three chances to disappoint.
You're up first, Andy.