Does a team that has lost 13 of its past 16 road games deserve to be a favorite in a divisional contest against an improving foe?
And when you consider Arizona's recent record in St. Louis, betting against the 4-0 Cards doesn't seem to make a lot of sense. They have visited their NFC West foes seven times in seven reasons and won seven times (covering five times and just missing by half a point and one point the other two times).
The point spread was attracting most of the interest in Vegas, but the total was also an intriguing scenario. Before last season's 23-20 meeting played over the total, these teams had played seven straight UNDERs, making bettors look hard at the 39 over-under at some shops.
Rams fans continue to take heart from their team’s turnaround so far under coach Jeff Fisher. And after trying to make their Thursday night game seem like a regular week they feel they can handle a Cardinals team that was lucky to escape Week 4 with a victory.
Arizona beat Miami in overtime, after Kevin Kolb led a game-tying TD drive in the final minute. His fourth-down TD pass with 22 seconds left forced the extra period. Even with the win, they failed to cover the spread.
Many experts feel the Cardinals' bubble can burst Thursday.
Pick: Based on purely statistical handicapping efforts, we play on the Rams here. There is a key "yards per point" angle that is tilted heavily in favor of St. Louis and we follow that stat here. (courtesy of PickShark.com)
Mike Pickett is a Contributor for Bleacher Report.