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On the opposite end, Kain Colter and Ventric Mark will need to play like they have been in the past couple of games in order to beat the Lions on the road.
Siemian is a young quarterback with a lot of promise, but to ask him to carry the load is hoping for too much.
Instead, look for Pat Fitzgerald to run the ball and do it often with Mark and Colter to cause Penn State's defense to play off-balance and keep Lions defensive coordinator Ted Roof guessing.
In terms of defense, they'd be smart to key in on the run against the Lions.
While McGloin has played surprisingly well (fourth in total offense in Big Ten), the Lions did so well offensively against Illinois last week because the passing and running game complemented each other.
Sure, McGloin passed the ball efficiently (18-of-30, 211 yards, 1 touchdown, 0 INTs), but the running by Zach Zwinak (19 carries, 100 yards, 2 touchdowns) and Bill Belton (16 carries, 65 yards) paved the way toward offensive balance against the Illini.
If Northwestern is able to neutralize the run and make McGloin pass 40 times, the Wildcats' chances at victory will be pretty favorable.