San Francisco 49ersDownload App

Buffalo Bills at San Francisco 49ers Preview and Predictions

Aaron NaglerNFL National Lead WriterOctober 24, 2016

After failing to put the New England Patriots away when they had the chance, the Buffalo Bills ended up on the unfortunate end of a beatdown against their division rivals. Now, they have to travel across the country and face one of the hardest-hitting teams in the league.

The San Francisco 49ers got back on track by punching the New York Jets in the mouth. You can expect more of the same when they welcome the Bills.

Ryan Fitzpatrick throwing four touchdowns and four interceptions won't happen again—mostly because he's not throwing four touchdowns against this Niners defense. 

Alex Smith doesn't need to do much other than hand the ball off to Frank Gore and Kendall Hunter and take the occasional shot downfield to Vernon Davis. It's Football 101, and the 49ers are doing better than anyone in the league. Pity the Bills defense. 

In the video above, we look at the big matchups and predict the score. Let us know what you think.

Where can I comment?

Stay on your game

Latest news, insights, and forecasts on your teams across leagues.

Choose Teams
Get it on the App StoreGet it on Google Play

Real-time news for your teams right on your mobile device.

Copyright © 2017 Bleacher Report, Inc. Turner Broadcasting System, Inc. All Rights Reserved. is part of Bleacher Report – Turner Sports Network, part of the Turner Sports and Entertainment Network. Certain photos copyright © 2017 Getty Images. Any commercial use or distribution without the express written consent of Getty Images is strictly prohibited. AdChoices