After failing to put the New England Patriots away when they had the chance, the Buffalo Bills ended up on the unfortunate end of a beatdown against their division rivals. Now, they have to travel across the country and face one of the hardest-hitting teams in the league.
Ryan Fitzpatrick throwing four touchdowns and four interceptions won't happen again—mostly because he's not throwing four touchdowns against this Niners defense.
Alex Smith doesn't need to do much other than hand the ball off to Frank Gore and Kendall Hunter and take the occasional shot downfield to Vernon Davis. It's Football 101, and the 49ers are doing better than anyone in the league. Pity the Bills defense.
In the video above, we look at the big matchups and predict the score. Let us know what you think.