We all know what happened on Monday night as the Seahawks won on a last-second touchdown that wasn't caught, but with the replacement refs gone as of Thursday night, Pete Carroll's boys will have to win on their own in Week 4.
The Rams, on the other hand, have been wildly inconsistent so far. In Week 1, Sam Bradford fell to fellow former No. 1 overall pick Matthew Stafford in Detroit, but followed that up with a feel-good win over Robert Griffin III and the Redskins.
Last week the Bears beat up on the Rams, and heading into Sunday's game against the Seahawks, St. Louis is in dire need of a bounce-back performance.
As we close in on what should be a pivotal game for these divisional rivals, let's take a closer look at what's in store for the Seahawks and Rams on Sunday.
Where: Edward Jones Dome
When: Sunday, 1 p.m. ET
Watch: Fox (Check local listings)
Listen: ESPN 710 (Seattle), ESPN 101 (St. Louis)
Live Stream: NFL Sunday Ticket
Money Line: Rams +115, Seahawks -135
Records aside, there isn't a heavy favorite in this one as the Seahawks are very fortunate to be entering Week 4 with a winning record. That being said, though the Rams looked decent against the Lions in Week 1, and even better against the 'Skins in Week 2, they haven't demonstrated any kind of consistency.
The jury's rightfully still out on Russell Wilson, but if he can string together a couple more wins, expect Vegas to start showing him more respect.
Tied for the lowest over/under of any Week 4 matchup (along with the Arizona-Miami game), the over has to look somewhat intriguing for this one.
However, the Seahawks haven't yet put up more than 27 points in a game, and none of their three scores have exceeded 39 points. St. Louis has been a bit more explosive, notching 31 points in Week 2, and combined with Washington for 59 points in that game.
Unless Wilson and Bradford put up uncharacteristically dynamic offensive performances, expect this contest to be a low-scoring affair.
Injury Report (via The Seattle Times)
Seattle: DT Greg Scruggs (limited in practice), DT Jaye Howard (limited in practice), DT Jason Jones (did not practice), LB Leroy Hill (did not practice), G John Moffitt (did not practice), T Breno Giacomini (did not practice)
St. Louis: OT Wayne Hunter (limited in practice), DT Michael Brockers (limited in practice), RB Steven Jackson (did not practice), DT Matt Conrath (did not practice), S Matt Daniels (did not practice), LT Rodger Saffold (did not practice)
Big Fantasy Plays
Seahawks: Marshawn Lynch
With 305 yards through the season's first three games, Marshawn Lynch has been Seattle's most dynamic offensive threat.
Though he's only found the end zone once so far in 2012, he has a history of putting points on the board against the Rams as he rushed for scores in both of Seattle's games against St. Louis last season.
It also helps that in St. Louis' first three games, running backs have scored a combined four touchdowns against the Rams defense.
Rams: Danny Amendola
Though Danny Amendola doesn't exactly have the greatest track record against Seattle (no touchdowns and just 110 yards in three career games), the undersized receiver has put up decent numbers through the first three weeks of the season.
In Week 2 against Washington, Amendola hauled in 15 catches for 160 yards, and with Steven Jackson listed as a game-time decision, the Rams may be forced to lean more heavily on the passing game this Sunday.
Key to Seahawks Win: Continued success against Sam Bradford
In his last four meetings with Seattle, Sam Bradford has won just once, which came all the way back in 2010.
More importantly, in the Seahawks' last three games against the Rams, Bradford has thrown for just one touchdown while tossing three picks along the way.
Who will throw for more yards on Sunday?
If Seattle's defense can continue to torment Bradford, they'll be in a good position to come out of Week 4 with a win.
Key to Rams Win: Picking up the slack if Steven Jackson is out
As of now, Steven Jackson's status for Sunday is uncertain, and if he's ultimately ruled out for Week 4 the Rams will need to find other ways to generate offense.
Daryl Richardson's play with Jackson in the lineup has been reasonably impressive, with 119 yards on 21 attempts, but the rookie back will be counted on to contribute if Jackson's out.
Otherwise, the Rams will need Bradford to have a big day, and if history is any indication, the chances of that happening aren't working in St. Louis' favor.
Seahawks 24, Rams 13