First blood this season might have gone to Los Blancos in the UEFA Super Cup, but it is a whole different story in the league. Manager Tito Vilanova has hit the ground running as the new man behind the Catalan giants, with six wins in as many games.
Meanwhile, manager Jose Mourinho's side have struggled to find their feet, having lost to Sevilla and neighbours Getafe already.
Barcelona, however, have injury problems and Madrid could be poised to close the gap with the three points on offer at the Camp Nou.
Let us take a look at who Vilanova could start, as Barca look to ensure they maintain their early lead in the league.