Mitch Stringer-US PRESSWIRE
Last year, Buffalo's comeback win over the Patriots snapped a ridiculous 15-game losing streak that dated back to the season opener in 2003, which marks the last time Tom Brady's squad had a losing record until now.
In Week 3 against a mighty Ravens team in Baltimore, New England looked to have command of the game, up nine in the fourth quarter.
But poor defensive play led to the Patriots relinquishing their lead, and the Ravens won on a last-second field goal.
For the Bills, they've rebounded nicely after being destroyed by the Jets on the road in Week 1. The offensive line has dominated and the defensive line has nine sacks in two games.
The availability of injured running backs Fred Jackson and C.J. Spiller will have a drastic effect on this AFC East showdown, as will the consistency of quarterback Ryan Fitzpatrick.
According to the team's official Twitter account, a return for Jackson is 70-75 percent likely. Spiller, though less likely to play, has yet to be ruled out.
This one will be another highly entertaining, competitive game.
But coming off two losses, Brady and Co. get back on track with a spirited and gritty win in Buffalo.
Patriots 31 Bills 27
X-Factor: Wes Welker
A week ago, many believed Welker was on his way to being phased out of the Patriots' offense. He then snagged eight passes for 142 yards against Baltimore. In the loss to the Bills last year, Welker had 16 receptions for 217 yards and two touchdowns.