The Bills find themselves in an unusual situation: looking down at the defending AFC champs in the division standings.
Buffalo has been successful in large part to its running back depth, which will be tested yet again in this matchup. Not only did starter Fred Jackson go down with injury, but last week, C.J. Spiller did as well. It will be up to Tashard Choice to maintain the integrity of the Bills' running game.
The Patriots will be counting on Brady to bring the team back to .500 and avoid a third straight loss.
When was the Patriots' last streak of three consecutive losses, you ask? Try October of 2002, when New England lost to the San Diego Chargers (quarterbacked by Drew Brees) and then went on to lose all three of its games in October (the Patriots drew a Week 7 bye).
Enjoy our preview of this compelling AFC East matchup, featuring an assortment of our NFL lead writers, and leave us your thoughts on the game in the comments below. Thanks for watching.