The England forward scored two brilliantly taken goals either side of Gareth Bale strike to give Villas-Boas his first victory as Spurs manager. The move elevates the Lilywhites to 10th in the Premier League with a home game against QPR up next before a tough trip to Old Trafford and Manchester United.
Spurs were deserved winners as they bossed a poor Reading team around for pretty much the entire game. Moussa Dembele was excellent in midfield, providing power and penetration from deep, while Gylfi Sigurdsson provided guile and intelligence from behind Defoe in a 4-5-1 formation.
The win provided a much needed three points for Villas-Boas amid ridiculous reports in The Sun that the Portuguese had three games to save his job.
Here we look at the lessons we learned from the match.
Read on and leave your comments and observations in the section below.