Leaders in San Francisco for 49ers-Lions:

Matthew Stafford, Lions: 230 passing yards, one TD, one INT

Alex Smith, 49ers: 226 passing yards, two TDs

Frank Gore, 49ers: 89 rushing yards, two receptions, 16 receiving yards, one TD

Calvin Johnson, Lions: eight receptions, 94 receiving yards

Vernon Davis, 49ers: five receptions, 73 receiving yards, two TDs

First half leaders in San Francisco for 49ers-Lions:

Matthew Stafford, Lions: 67 passing yards, one INT

Alex Smith, 49ers: 82 passing yards, one TD

Frank Gore, 49ers: 62 rushing yards, one TD

Calvin Johnson, Lions: three receptions, 36 receiving yards

Vernon Davis, 49ers: two receptions, 33 receiving yards, one TD

Leaders in St. Louis for Redskins-Rams:

Robert Griffin III, Redskins: 206 passing yards, 82 rushing yards, three total TDs (two passing, one rushing), one INT

Sam Bradford, Rams: 310 passing yards, 10 rushing yards, three passing TDs, one INT

Daryl Richardson, Rams: 83 rushing yards, two receptions, 19 receiving yards

Alfred Morris, Redskins: 89 rushing yards, 

Danny Amendola, Rams: 15 receptions, 160 receiving yards, one TD

Leonard Hankerson, Redskins: two receptions, 68 receiving yards, one TD

Leaders San Diego for Chargers-Titans: 

Jake Locker, Titans: 174 passing yards, one TD, one INT

Philip Rivers, Chargers: 284 passing yards, three TDs, one INT

Jackie Battle, Chargers: 69 rushing yards, two TDs

Kendall Wright, Titans: two receptions, 24 receiving yards, one TD

Malcom Floyd, Chargers: six receptions, 109 receiving yards

Donte Rosario, Chargers: four receptions, 48 yards, three TDs

Leaders in Pittsburgh for Steelers-Jets: 

Ben Roethlisberger, Steelers: 275 yards passing, two TDs

Santonio Holmes, Jets: three receptions, 28 yards receiving, one TD

Antonio Brown, Steelers: seven receptions, 79 receiving yards

Mike Wallace, Steelers: five receptions, 74 receiving yards, one TD

Mark Sanchez, Jets: 138 passing yards, one TD

Leaders in Seattle for Cowboys-Seahawks: 

Tony Romo, Cowboys: 251 yards passing, one TD, one INT

Russell Wilson, Seahawks: 151 yards passing, one TD

Marshawn Lynch, Seahawks: 122 yards rushing, one TD

Miles Austin, Cowboys: five receptions, 63 yards receiving, one TD

First half leaders in Pittsburgh for Jets-Steelers: 

Mark Sanchez, Jets: 80 yards passing, one TD. 

Ben Roethlisberger, Steelers: 148 yards passing, one TD.

Santonio Holmes, Jets: Two catches, 25 yards, one TD. 

Shaun Suisham, Steelers: 2/2 field goals, both from 45 yards.

First half leaders in St. Louis for Redskins-Rams:

Robert Griffin III, Redskins: 110 yards passing, 30 yards rushing, two total TDs, one INT. 

Danny Amendola, Rams: 12 catches, 133 yards, one TD. 

Sam Bradford, Rams: 181 yards passing, one TD. 

Leonard Hankerson, Redskins: Two catches, 68 yards, one TD (66 yards). 

Steven Jackson, Rams: 58 yards rushing. 

First half completed in Seattle. Here's the fantasy leaders so far in Cowboys-Seahawks:

Miles Austin, Cowboys: Four catches, 48 yards, one TD. 

Seattle defense/special teams: Seven points allowed, punt block for touchdown. 

Tony Romo, Cowboys: 14-of-26 for 170 yards, one TD, one INT. 

DeMarco Murray, Cowboys: 67 total yards (36 rushing). 

Scott Rovak-US PRESSWIRE

PPR explosion alert: Rams receiver Danny Amendola has 12 catches for 133 yards and a touchdown against the Washington Redskins...in the first half.

The NFL record for receptions is 21, set by Brandon Marshall in 2009. Amendola will have a chance to break that mark with a solid second half. Either way, he's had a monster fantasy day.

Jeff Curry-US PRESSWIRE

Another touchdown for Robert Griffin III. In the second quarter, the No. 2 overall pick went deep to Leonard Hankerson for a 66-yard touchdown, putting Washington up 21-6 over the Rams. 

Griffin III now has 110 yards passing, 15 yards rushing and two total scores. 

Washington Redskins quarterback Robert Griffin III ran in his first NFL touchdown Sunday in St. Louis on a five-yard scamper. 

Griffin has now thrown for 30 yards and rushed for 15 more through the first quarter. The Redskins lead, 14-3. 

The Houston Texans running-back duo of Arian Foster and Ben Tate combined for a whopping 244 yards in Sunday's 27-7 win over the Jacksonville Jaguars.

Foster ran for 110 yards and added 37 more receiving, while Tate rushed for 97. The two combined for three scores. Both backs remain valuable in any league as long as the touches and production remain as consistent as they have been through two games.

Mark Sanchez continued his terrific start to the 2012 by leading the New York Jets to a first-quarter touchdown in Pittsburgh. 

Sanchez hit Santonio Holmes on a 12-yard score to finish off the drive. He now has four touchdown passes in 2012. 

Anthony Gruppuso-US PRESSWIRE

Top fantasy performances from the early games:

Eli Manning, Giants: 510 passing yards, three touchdowns, three interceptions.

Andy Dalton, Bengals: 318 passing yards, three touchdowns, one interception.

Reggie Bush, Dolphins: 26 rushes, 172 yards, two touchdowns.

Arian Foster/Ben Tate, Texans: 184 yards rushing, three touchdowns. 

C.J. Spiller, Bills: 180 (123 rushing) total yards, two touchdowns. 

Dwayne Bowe, Chiefs: Eight catches, 102 yards, two touchdowns. 

Cam Newton, Panthers: 253 yards passing, one touchdown; 71 yards rushing, one touchdown.

Darren Sproles, Saints: 13 catches, 128 yards.

The Star-Ledger-US PRESSWIRE

Hakeem Nicks, Giants: 10 catches, 199 yards, one touchdown.

Victor Cruz, Giants: 11 catches, 179 yards, one touchdown. 

Vincent Jackson, Bucs: Five catches, 128 yards, one touchdown. 

Trent Richardson, Browns: 145 total yard (109 rushing), two touchdowns.

Brent Celek, Eagles: Eight catches, 157 yards.

US PRESSWIRE

The top performance from a tight end in the early games clearly goes the Eagles' Brent Celek, who now has eight catches for 157 yards.

The yardage total is a franchise record for a tight end and Celek's career high. 

John Rieger-US PRESSWIRE

In an otherwise lost day for the Kansas City Chiefs, receiver Dwayne Bowe caught two second-half touchdowns. 

Bowe has eight catches for 102 yards and two scores in a blowout in Buffalo. 

Another touchdown toss for Eli Manning, who has now broken the Giants franchise record for passing yards. He has 436 yards with three touchdowns and three interceptions today, as the Giants now lead the Buccaneers late in the fourth quarter.

Eli Manning revived a dead fantasy day (and the Giants hopes of not starting 0-2) when he hit Victor Cruz for an 80-yard touchdown in the fourth quarter against the Tampa Bay Buccaneers. Manning is now nearing 400 passing yards with two scores. 

Dale Zanine-US PRESSWIRE

Jaguars quarterback Blaine Gabbert has left Jacksonville's game against the Texans with a leg injury, and he's been replaced by backup Chad Henne.

Gabbert is not likely to return. 

The 2011 first-round pick was poor before the injury, completing just 7-of-19 passes for 53 yards and one touchdown. The Jaguars are currently down, 24-7. 

Raiders receiver Denarius Moore has been replaced in Miami after dealing with cramping issues.

He currently has three catches for 67 yards. 

Kelce, right, likely has a major knee injury.
David Richard-US PRESSWIRE

Potentially devastating injury news for the Eagles, who lost center Jason Kelce to a really bad-looking knee injury. 

It's officially being called a sprain, but replays showed that Kelce likely torn ligaments in his right knee as he buckled from the outside in.

Receiver Jeremy Maclin was also carted off in obvious pain. He's since returned to the sidelines, but his status is up in the air.  

Kelley L Cox-US PRESSWIRE

Chargers running back news: Curtis Brinkley is starting for San Diego Sunday in place of Ryan Mathews.

Ronnie Brown started last week's win over the Oakland Raiders, but looked completely overmatched. If you're in need of a last-second running back, Brinkley isn't the worst option. 

Browns running back Trent Richardson has his second touchdown of the day, this one a 23-yard touchdown pass from Brandon Weeden.

Richardson now has 124 total yards and two scores. 

Dolphins running back Reggie Bush now has two second-half touchdown runs, including a 65-yarder moments ago. He's well over 100 yards rushing at 129 on 17 carries.