So what can they expect out of their healthy RBs in Week 2?
Jackson sprained his right LCL on a hit that looked like it was certainly going to be season-ending. So the prognosis of him possibly being back within a month is good news for a team looking to take any positive out of that debacle.
C.J. Spiller, who filled in for an injured Jackson in the final six games of last season, now assumes the starting role.
He had a career day on Sunday with 169 yards and a TD on only 14 carries. Not that it mattered, as Ryan Fitzpatrick looked terrible in throwing three INTs.
The new-look Bills defense also turned in a pathetic performance, making an average Jets offense look like they were the best in the league.
So what's the game plan for Sunday against the Kansas City Chiefs?
Ahead, we'll look at three things to expect from the Bills RBs in that game as they look to erase the memory of the opener as quickly as possible.