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This is another intriguing fixture, much like the Manchester United one I spoke about earlier.
Stoke are an excellent side, and they have a good manager in Tony Pulis.
They're tremendously well-supported, especially at home, where the Britannia Stadium is like a cauldron at times.
Is there a styles clash here? Maybe.
Stoke are normally pegged as just a physical side, but they've added some excellent footballers to the squad over the last couple of years, which sometimes goes unnoticed.
On the other hand, City have a squad full of world-class footballers and their attacking options are frightening.
I was a little surprised by the signing of Scott Sinclair because, to be honest, I've never really seen what all the fuss was about with him.
It could be another potential debutant that has the final say over this fixture.
One of England's all-time leading goalscorers could make his Stoke debut this weekend, and what better way for him to introduce himself to the Stoke fans than with a winner against Manchester City?
If he's fit, then I certainly wouldn't bet against it!