The two teams have displayed animosity toward one another before.
With talk that the Saints had a bounty out on Cam Newton a year ago, that animosity figures to only increase in the week two matchup.
And with the way the Panthers have played the Saints over the years, Saints fans should be very weary about the possibility of the team starting 0-2 for the first time since 2007. The Panthers are not a team to be taken lightly.
Last week's ugly home loss to the Redskins ought to be enough reason for concern. Add to that the way the Panthers regularly compete and battle the Saints, and this game is a dangerous one for New Orleans.
Here are five ways the Saints can overcome the Panthers in this crucial week two game.