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The obvious top pick in smaller leagues is Buffalo's C.J. Spiller, with the news that 31-year-old Fred Jackson is (surprise!) hurt again.
Spiller was unbelievable in Jackson's absence last season and kept form on Sunday with an absolute fantasy monster.
Too bad nobody started him.
But here's some pickups for 12-team leagues.
Alfred Morris, Washington Redskins
My worst fear—and the biggest headache a fantasy owner can take on—is a Mike Shanahan running back in recent seasons.
It used to be that Shanahan polished relatively unknown runners into serviceable options like Olandis Gary or beasts of fantasy dominance like Terrell Davis. All he needed was a runner who could "make one cut and go," the type of runner that would simply execute their assignment, then benefit from the fantasy rewards of the zone-blocking system.
But the problem is he hates you; Mike Shanahan hates you.
Understand this before putting in that waiver claim over one of the available WRs (or bidding your entire season budget as some are ridiculously doing) on Morris because he scored two touchdowns in Week 1.
If you are needy at RB and have an early waiver spot, scooping Morris up is a no-brainer. A headache is better than a death sentence. You've had your initial look at your team and, hopefully, your players; you have an idea of what might be missing.
Best case, Alfred Morris becomes at top-12 fantasy RB. Robert Griffin could put on a Cam Newton mask and ignite that whole offense to new heights with Morris setting the pace on the ground.
Worst case, Morris "starts" next week and gets four carries for seven yards, while Roy Helu gets heavily involved in the screen game for a 185-yard explosion. Then, you realize that Shanny is playing the matchup and keeping his opponent off-balance the same way he is doing to you.
Dexter McCluster, Kansas City Chiefs
Fifty-seven snaps and 10 targets in the opener for Kansas City's offense? McCluster is basically a WR with RB eligibility in most fantasy leagues, which makes his upside most valuable in PPR leagues, but the value is there for standard scoring as well.
The worries of a crowded backfield in Kansas City, one featuring Peyton Hillis and Jamaal Charles, should be tabled for now. McCluster is used in his own way, and he was a player whom many thought former OC Todd Haley did not know (or care to figure out) how to properly utilize.
I love the prospect of this kind of weapon in an AFC West offense as a bench stash to plug in at the flex against great matchups. This is the time when you have to grab those guys. Soon, the wire will be dry as a bone.
This week's waiver-wire RB slate is obviously stacked heavy at the top. Alfred Morris may be the biggest pickup of the season.
For some reason, though, it reminds me of the time Ryan Grant got hurt and everyone went crazy on Brandon Jackson. Take a stab if you can, but be smart. If you are putting in a blind bid, keep it around 25 percent of the absolute max.
Others of Note
Jacquizz Rodgers, Atlanta Falcons
In PPR leagues, he was better this week than Michael Turner. This is no longer a Mike Mularkey offense, and while I am not rendering Turner totally useless, I would recommend picking up Rodgers to owners in all 12-team leagues putting in later waiver-position claims, especially Turner owners who haven't yet rostered Rodgers.
Knowshon Moreno, Denver Broncos
I don't love him, but he seems to have found some sort of niche in and around goal-line sets, judging on what we've seen. Willis McGahee is still serviceable as the starter, but it appears that Moreno will handle the duties if he is unavailable, and let's face it, McGahee is old and close to being done.