And who can forget how the last one ended with a last second 49ers touchdown and the altercation between Jim Schwartz and Jim Harbaugh?
Well, in Week 2, the newfound rivalry renews and both teams enter with 1-0 records. However, they came about that record in different manners.
For the 49ers, it was a solid victory on the road over Green Bay, while St. Louis took Detroit down to the wire before Kevin Smith secured the win for the Lions.
Week 2 should be a dandy between these two squads, with a 2-0 record on the line and early bragging rights for NFC supremacy.
Watch Bleacher Report's preview of this Week 2 NFC matchup, and leave your own preview and prediction below.
For all your 2012 NFL coverage including previews and predictions, breaking news, fantasy analysis, in-depth profiles and anything else across the league, stay with Bleacher Report Productions.
The Pro Show: Game previews and predictions, rumors, analysis and more
Fantasize Me: The best advice on your fantasy team, including analysis from Arian Foster