The Carolina Panthers (0-1) and Tampa Bay Buccaneers (1-0) faced off in the first NFC South matchup of the year in Tampa, Florida.
Carolina dominated the Bucs last season, winning 38-19 on the road in Week 13 and 48-16 at home in Week 16, but Tampa Bay controlled the action in the first game of the season for both teams.
Cam Newton threw for 303 yards and a touchdown, but he also threw a couple of second half interceptions to thwart Carolina's chances.
Carolina ran for a franchise-tying low 10 yards against last season's 32nd ranked rush defense.
The Bucs' Josh Freeman finished the game 16-of-24 for 138 yards and a touchdown after completing 12 of his first 14 first half attempts.
Carolina has a lot of work to do before hosting the New Orleans Saints (0-1) at Bank of America Stadium.