Peyton Manning will be looking to complete his successful return to the field following multiple neck surgeries against an organization that has long been regarded as having one on the league's best defenses.
Willis McGahee will be out to prove that his 2011 campaign, in which he ran for 1,199 yards, the third highest total in his career, was no fluke.
Von Miller won the Defensive Rookie of the Year award after posting 11.5 sacks and he is poised to become one of the league's top defensive players.
There will be 50 other players looking to contribute and help the Broncos start 1-0 for the first time since a 12-7 victory over Cincinnati in 2009 that was really only a victory due to a incredibly lucky play.
Here is a look at the top 10 performances in Broncos history in season opening play.